Heart cancer (primary cardiac tumor) is cancer that arises in the heart. Cancerous (malignant) tumors that begin in the heart are most often sarcomas, a type of cancer that originates in the soft tissues of the body. The vast majority of heart tumors are noncancerous (benign).
Although still rare, most cancers found in the heart have come from elsewhere in the body.
Cancers that begin near the heart, such as lung cancer, can grow to involve the heart or the lining around the heart (pericardial sac).
Or cancer can begin elsewhere in the body and spread to the heart through the bloodstream. Cancers that may affect the heart include breast cancer, kidney cancer, lung cancer, leukemia, lymphoma and melanoma, among others.
Cancer can affect the heart in other ways, as well.
A rare type of cancer known as carcinoid tumor at times produces hormones that can damage heart valves. Cancer treatments also can damage the heart.
Cancer treatments linked to heart problems include several types of chemotherapy drugs, certain targeted therapy drugs, radiation therapy aimed near the heart, and hormone therapy. Some heart problems are detected during treatment, while others may not become apparent for many years after treatment.
In vitro differentiation of embryonic stem cells (ESCs) to cardiomyocytes has a potential Clinical application in treatment of cardiovascular defects. Also, cardiomyocyte Differentiation of ESCs can be used as a model to study the molecular and cellular Mechanisms underlying cardiovascular development. This study sought to investigate the presence of oxytocin receptors and the possible biological role of oxytocin as an effective factor in the differentiation of ESCs into cardiomyocytes. Bioinformatic methods and softwares such as UCSC and Genome Browser which can search for the blat of sequences were used to get information about the sustainability of the surface of nucleotide; Ebi clustalw was used for pairing. SSC profiler was used in 1000 nucleotide window to determine the sequence of mir; CidmiR was used to identify the completely new sequences of mir; RNAfold was used to analyze the secondary structures of RNA. Having used the methods mentioned above a miRNA was found in the fourth intron of this gene.
Protozoa are one-celled animals found worldwide in most habitats. Parasitic infections due to protozoa and helminthes account for a great burden of morbidity and mortality in extensive areas of the world, especially in developing countries. The protozoans known to involve the heart are a diverse group. Chagas disease, caused by the protozoan Trypanosoma cruzi, remains one of the most prevalent parasitic diseases in Latin American, and has become a health problem in non-endemic countries as a result of widespread migration. This disease is transmitted to humans by infected triatomine bugs, or occasionally, by blood transfusion, organ transplantation, congenital transmission or oral ingestion of contaminated materials. According to the information described, while doing research to find a novel approach for diagnosing and treating chagas based on Protozoa and during the replacement of normal tissue with abnormal tissue of the atrium of heart via Protozoa, the research team has discovered that it could a new vista for the restoration of abnormal tissue and improved technique of heart’s cell transplantation. Select proper building materials, construction methods and results summarized as follows: Initially, genetic associations between Protozoa and the one leading to chaga disease are identified from a pool of genetic variations associated with these diseases, using Genome Wide Association Study (GWAS), an approach used for rapidly scanning markers across the complete sets of DNA or genomes. At a subsequent stage, molecular genetics laboratory techniques were used to analyze gene–gene or protein–protein interactions and also identify some new genes responsible for chaga disease as reliable markers for diagnosis and treatment. At the end, the damaged atrium by Protoza has been completely recovered via the new technique which is called: conformation of autologous adult stem cell transplantation, paracrine mechanisms and mesenchymal stem cell therapy (APM).
A heart tumor consists of a lot of grown cells which have been created in an unsuitable location in the heart. When individuals are exposed to known or unknown environmental and genetic factors, disorders happen. These disorders change the expression of genes or a collection of genes which can have an influential role in the creation of genes. With the help of Expressed Sequence Tags (EST), the present study tries to predict and detect the genes that are effective in heart cancer in the cDNA library in the NCBI database. The results showed that ribosome subunit coding genes, especially small subunits, are over expressed in the cancer tissues of heart. In contrast, membrane transport protein genes, like myelin basic protein (MBP), are under expressed in the cancer tissues of heart. The results of this study include an accurate report of genes that are influential in heart tumor. They can be used to better detect the disease and improve the treatment procedure.
Genes associated with homogenous disorders indicates both higher plausibility of somatic interactions between their products and higher expression portraying similarity for their transcripts, underpinning the existence of distinct disease-specific utilitarian modules. A network of cardiovascular disorders and disease genes linked by known disorder–gene associations making overtures to a rostrum to traverse in a single graph-theoretic chassis all known phenotype and disease gene associations, the rules stipulates the quotidian genetic origin of cardiovascular diseases. The research team perceives that crucial human cardiovascular genes are presumably to encipher hub proteins and are expressed wide-ranging in significant cardiovascular tissues. Moreover, we find that the preponderance majority of cardiovascular disease genes are not needed and demonstrate no inclination to encode hub proteins, and their expression array stipulates that they are delimited in the functional rim of the network. As opposed to this advocates that cardiovascular disease genes also would play a vital role in the human interactome cardiovascular. A selection-based model makes intelligible the observed-significant difference between indispensable and cardiovascular disease genes and also gives the impression that diseases triggered by somatic mutations should not be circumferential, a prediction we endorse for heart cancer genes. In the end, Genetic Heterogeneity and Connectivity of Disorder Classes, Protein-Protein Interaction Data, Gene Ontology Analysis, Tissue Homogeneity, Gene Expression Microarray Data etc
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